Conservation biology aims to stop habitat loss and extinction of species. To achieve these goals there are several methods such as the establishment of natural reserves and national parks that in synthesis work as protected areas. However, the management of areas with high conservation priorities can be a challenge to conservation biology and all of the professionals involved in this process.The Colombian National Natural Park, Los Katios, hosts more than the 20% of Colombian biodiversity and is located in a region which is characterised as being one of the most biodiverse and endemic points on the planet. The park was declared a World Humanity Heritage Area in 1994 by the United Nations Educational, Scientific and Cultural Organization (UNESCO) and on the 8th of July 2009, the Colombian government solicited to the UNESCO World Heritage Committee the inclusion of the park on the list of World Heritage in Danger due to the pressures from illegal activities and inefficient surveillance in the area.Through the case of study of Los Katios National Natural Park, this review looks explores the extent to which the socio-economic situation and the internal crises of a country can influence the effectiveness of the conservation programs in protected areas. It also explains the relevance of National Natural Parks and the effects that some factors, such as violence; illegal crops; poverty; and environmental budget, can have on the performance of the conservation biology.This review concludes that the conservation of protected areas in countries with deep internal crises, such as in the case of Los Katios in Colombia, cannot be based solely on the fundamental conservation goals and that it is necessary to include government priorities and some strategies to counteract social issues as violence, poverty and insufficient funds when creating management plans.